Local and global spread of antibiotic-resistant microorganisms is a significant risk fac- tor for global health.
The persistence and spread of resistant microbial species and the binding of determi- nants at the human-animal-environment interface can alter microbial genomes, result- ing in resistant superbugs in various niches.
All associations/peoples involved motivated by a consolidated link between three ar- eas: human, animal and environmental health.
Several countries have implemented national action plans based on the One Health approach to combat antibiotic-resistant microbes, following the guidelines of the Food and Agriculture Organization (FAO) – World Organization for Animal Health (OIE) -World Health Organization (WHO).

Antimicrobials Resistance Origin and Diffusion
Nowadays, antimicrobial resistance (AMR) is intended as a “modern” micro- bial feature resulting from the unsuccessful and/or prolonged exposure to antibiotic treatments.

Pre-antibiotic era
However, the identification of antimicrobial resistance traits in ancient per- mafrost, isolated caves, and mummies witness the presence of the antimi- crobial features since remote times, and a distinction between innate and acquired AMR is currently employed.

Antibiotic era
The first is the result of a slow and long evolutionary process microorgan- isms have performed to adapt to the changing environmental conditions; while the second is the result of a “quick” adaptation to a sudden selec- tive pressure represented by the antimicrobial treatment”
Future of Antibiotics The antibiotic-resistant pathogens crisis needs ives- tigation of novel research for tackling the antimicrobial resistance to avoid reversion to the pre-antibiotic era of medicine.

AWP organized a number of research to design the antibiotic resistance breaker able
to re-sensitising resistant bacteria to antibiotics